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App Note

Enhancing Therapeutic Properties of a Cancer-Targeting Affibody by Soft Mutagenesis CVL Libraries

The Twist Structural scFv Library harnesses sequences from every antibody crystal structure in a worldwide protein structure database. By building on the knowledge of antibody structure-function relationships, this synthetic antibody library provides a platform for generating a wide range of antibodies for therapeutic indications.

  • How in silico designed Combinatorial Variant Libraries were uses to improve affibody therapeutic properties
  • Why when undertaking soft mutagenesis, in silico designed CVLs are superior to NNK and trimer libraries
  • What therapeutic advantages and opportunities affibody molecules offer over monoclonal antibodies
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