Quickly find dozens of antibodies
Quickly find dozens of antibodies
Quickly find dozens of antibodies
OVERVIEW
> 100,000 Different GPCR Binding Motifs

With over 100,000 different GPCR binding motifs, unlock the discovery of antibodies to this difficult-to-target class.

 

GPCRs are Hard-to-Drug
 
  • 30-50% of current drug targets are GPCRs but there are only 2 FDA approved antibodies

  • Current antibody drug development methods do not work

  • Random mutagenesis libraries are too inefficient to explore the effective 
sequence space
     
Synthetic Library Advantage
 
  • No immunization required
  • Synthetic mAb libraries focus on effective sequence space
  • Simultaneous screening against multiple targets
GPCR Binding Motifs
> 100,000 Different GPCR Binding Motifs

With over 100,000 different GPCR binding motifs, unlock the discovery of antibodies to this difficult-to-target class.

 

GPCRs are Hard-to-Drug
 
  • 30-50% of current drug targets are GPCRs but there are only 2 FDA approved antibodies

  • Current antibody drug development methods do not work

  • Random mutagenesis libraries are too inefficient to explore the effective 
sequence space
     
Synthetic Library Advantage
 
  • No immunization required
  • Synthetic mAb libraries focus on effective sequence space
  • Simultaneous screening against multiple targets
GPCR Binding Motifs
PROOF OF CONCEPT
Multiple Antibodies Bind GLP1R Over-Expressing CHO Cells and are Functional in a cAMP Assay
  • IgGs are monomeric and not prone to aggregation
  • Multiple FACS positive hits include GLP-1 and GLP-2 motifs as well as
    additional unique sequences.
GPCR Cellbinding
Multiple Antibodies Bind GLP1R Over-Expressing CHO Cells and are Functional in a cAMP Assay
  • IgGs are monomeric and not prone to aggregation
  • Multiple FACS positive hits include GLP-1 and GLP-2 motifs as well as
    additional unique sequences.
GPCR Cellbinding
RESOURCES