Access diverse and precisely defined synthetic antibody libraries and synthetic genes

Discover and optimize high quality antibody drugs in a time and resource efficient manner

High Quality and Diversity, Less Time

Decrease the time to IND by taking advantage of high diversity precisely defined libraries and automated workflows to reduce optimization cycles with Twist proprietary technology

Pursue Hard Targets

With our target class specific libraries, tackle hard-to-drug targets, e.g. GPCR

Broad Application

 Therapeutics focused with applications in diagnostics and reagents

Protect Confidentiality

Twist Biopharma is a division of Twist Bioscience

Twist mAb technology focuses on effective sequence space

Antibody characterization

• Affinity
• Receptor-ligand assays

In-vitro functional assay

Developability assessment

Affinity maturation: Powered by Twist Antibody Optimization (TAO) libraries

Druggability optimization by TAO

CHO stable pools to enable predevelopment activities

Next-generation naive synthetic antibody libraries, liability-free, inspired by natural repertoire

• Highly diverse

• Precisely defined

• Proprietary and unique

Explore mutation space from parent reference sequence & germline using natural LCDR1-3 and HCDR1-2 sequences derived from NGS data

Exclude liabilities and customer-identified sequences

Increase affinity and improve developability

Learn More

GPCR Antibody Library: Unlock & enable the discovery of antibodies to this difficult target class

VHH Nanobody and other scaffolds

"Target-class" specific libraries: Ion channels and transporters

Smart "Target" specific libraries generated utilizing:

1) Modeling tools and existing target crystal structures

2) NGS data derived from target immunized mice

Human Hyperimmune and Immunome Libraries: Fully synthetic naive libraries based on human NGS data

Learn More

Posters

TAO: Twist Antibody Optimization of an Anti-PD-1 Antibody

The Twist Antibody Optimization platform enables high-throughput, high-quality biophysical characterization of high-affinity, functional humanized antibodies

A High-Throughput Platform to Develop Highly Potent and Functional Antibodies against G-protein Coupled Receptors

The Twist High-Throughput Antibody Discovery platform identifies functional antibodies against GPCR targets within a few months

Flyers

Twist Biopharma Overview

Twist Biopharma provides end-to-end solutions in

biologic drug discovery and early development

GPCR Libraries

Unlock the discovery of antibodies to this difficult target class

Twist Antibody Optimization Platform

Quickly generate high-diversity, high quality molecules inspired by the human repertoire

Dive into Twist Biopharma's technologies and find out how you can elevate your research.

License ready-made libraries

Generate new leads against any GPCR

Optimize existing leads

Collaborate around select high-value leads

Partner with us to:

TWIST BIOSCIENCE ©2019